Piperacillin-tazobactam is More Effective Than Ceftriaxone Plus Gentamicin in Febrile Neutropenic Patients with Hematological Malignancies: a Randomized Comparison

Efficacy and costs of empirical antibacterial therapy in febrile neutropenic patients are important issues. Several strategies have been reported to be similarly effective: monotherapy with cefepime, ceftazidime or a carbapenem or duotherapy with an antipseudomonal β-lactam antibiotic or ceftriaxone in combination with an aminoglycoside. Piperacillin-tazobactam monotherapy is promising, but its role in this setting still has to be defined.