Identification and validation of the methylated TWIST1 and NID2 genes through real-time methylation-specific polymerase chain reaction assays for the noninvasive detection of primary bladder cancer in urine samples.

Isabelle Renard,Steven Joniau,Ben van Cleynenbreugel,Catherine Collette,Christophe Naômé,Ilse Vlassenbroeck,Hubert Nicolas,Jean de Leval,Josef Straub,Wim Van Criekinge,Wissem Hamida,Majed Hellel,Alexandre Thomas,Laurence de Leval,Katja Bierau,David Waltregny

European Urology（2010）

引用 149|浏览17

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摘要

Detection of the methylated TWIST1 and NID2 genes in voided urine samples using methylation-specific polymerase chain reaction assays provides a highly (≥90%) sensitive and specific noninvasive approach for detecting primary bladder cancer.

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关键词

Bladder cancer,Cytology,Gene promoter,Methylation,PCR,Urine

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