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The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor

Bioorganic & Medicinal Chemistry Letters, no. 9 (2006): 2525-2527

Cited by: 9|Views15
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Abstract

Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved by the presence of one or two basic amine functional groups.

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