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The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels

Bioorganic & Medicinal Chemistry Letters, no. 8 (1997): 1047-1052

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UK-78,282 was identified in a human T cell 86 Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blocker of human T cell voltage-gated K + channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communicat...更多

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