Cigarette smoke-induced pulmonary endothelial dysfunction is partially suppressed by sildenafil.
European Journal of Pharmaceutical Sciences(2010)
摘要
Cigarette smoke mediated oxidative stress and endothelial dysfunction are important processes in the pathogenesis of several lung disorders. In this study we evaluated the effect of PDE5 inhibition on pulmonary artery endothelial dysfunction induced by cigarette smoke in vitro.
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关键词
Sildenafil,Human pulmonary artery endothelial cells,Oxidative stress,Endothelial dysfunction
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