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Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Haixia Wang,Zheming Ruan,James J Li,Ligaya M Simpkins,Rebecca A Smirk,Shung C Wu,Robert D Hutchins,David S Nirschl,Katy Van Kirk,Christopher B Cooper,James C Sutton,Zhengping Ma,Rajasree Golla,Ramakrishna Seethala,Mary Ellen K Salyan,Akbar Nayeem,Stanley R Krystek,Steven Sheriff,Daniel M Camac,Paul E Morin,Brian Carpenter,Jeffrey A Robl,Robert Zahler,David A Gordon,Lawrence G Hamann

Bioorganic & Medicinal Chemistry Letters（2008）

引用 31|浏览59
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摘要
The synthesis and biological evaluation of a series of potent and selective pyridine amide 11β-HSD1 inhibitors is reported.
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关键词
11β-Hydroxysteroid dehydrogenase type 1,11β-HSD1,Pyridine amide
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