SPORANDOL: A NOVEL ANTIPARASITIC BINAPHTHALENE FROM CHRYSOSPORIUM MERIDARIUM

Athanasios Tsipouras*,Michael A. Goetz,Otto D. Hensens,Jerrold M. Liesch,Dan A. Ostlind,Joanne M. Williamson,Anne W. Dombrowski,Richard G. Ball,Sheo B. Singh*

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1997）

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摘要

Sporandol (7, 7'-diacetyl-1, 1', 8, 8'-tetrahydroxy-3, 3'-dimethoxy-6, 6'-dimethyl-2, 2'-binaphthalene, 1) a novel endo and ecto parasiticide has been isolated from Chrysosporium meridarium. This compound appears to have much less mammalian toxicity than other members of the binaphthalene class. Axial stereochemistry of sporandol was determined as S by CD measurements. (C) 1997 Elsevier Science Ltd.

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