2,5-Pyridinedicarboxylic acid derivatives as non-nucleosidic reverse transcriptase inhibitors of hepatitis B virus.

Bioorganic & Medicinal Chemistry Letters, pp. 2715-2717, 2002.

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摘要

2,5-Pyridinedicarboxylic acid derivatives were found to be the potent non-nucleoside inhibitors of hepatitis B virus (HBV) with IC50 ≤0.01μg/mL in a reverse transcriptase inhibitory effect. And they showed the low toxicity compared with the nucleoside analogues.

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