Pharmacological Treatment of Gilles de la Tourette??s Syndrome:

Although the pathophysiology of Gilles de la Tourette’s syndrome is still unknown, effective symptomatic therapies are available. Antipsychotic drugs are the most effective agents for suppressing motor and vocal tics. Haloperidol is the most widely used drug, but pimozide — a closely related drug — is our drug of first choice. Other groups prefer clonidine as the initial treatment. We found a good clinical effect in 81 % of patients treated with either pimozide alone or in combination with tetrabenazine. Clonidine or sulphide have also been used in combination with pimozide with beneficial effect in some patients.