Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

Michael A. Goetz,Otto D. Hensens,Deborah L. Zink,Robert P. Borris,Francisco Morales,Giselle Tamayo-Castillo,Robert S. Slaughter,John Felix,Richard G. Ball

TETRAHEDRON LETTERS（1998）

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摘要

The isolation and structure elucidation of two novel nor-triterpenoid K(V)1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. (C) 1998 Elsevier Science Ltd. All rights reserved.

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关键词

K-v1.3 channel blockers correolide and dehydrocorreolide,isolation and structure,2D NMR,HMBC,EI-MS,X-ray

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