Novel tandem triplication of 1q in a patient with a myelodysplastic syndrome.
Cancer genetics and cytogenetics(1984)
摘要
This is a report of a patient with a myelodysplastic syndrome characterized by symptomatic neutropenia whose bone marrow aspirates have consistently demonstrated an unusual cytogenetic anomaly. The abnormality present in all metaphases consisted of a tandem triplication of a portion of the long arm of chromosome #1, resulting in tetrasomy of a section of this chromosome ( 1q21 -32). Duplications of this portion of chromosome #1 were observed as a nonrandom event in various malignant states. In addition, these precise breakpoints can be increasingly correlated with tandem duplications.
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关键词
myelodysplastic syndrome,novel tandem triplication,1q
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