Computer simulation as an aid to incorporating diffusion effects into multicompartment models of Na exchange in tissues
Annals of Biomedical Engineering(1978)
摘要
Digital computer simulation is used to determine the effects on calculated transport rate constants and relative compartment
sizes caused by incorporating mathematical expressions for diffusion out of the extracellular space into compartmental models
of Na kinetics. Four typical records were selected from sets of Na tracer washouts (kidney cortex, papillary muscle, carotid
artery-control, and aldosterone treated) illustrative of widely differing patterns of Na distribution. Each record was analyzed
first using a strictly compartmental model and then using a diffusional-compartmental model. Only for the kidney cortex tissue
did inclusion of the diffusion constraints permit the model to be reduced from three to two compartments. The effects of the
diffusion constraints on the three compartment models for the carotid and papillary tissues were more pronounced in the carotid,
which is characterized by a predominantly extracellular localization of Na, than in the papillary tissue, which has its Na
more equally distributed between three compartments. Furthermore, differences between the control and the aldosterone treated
carotid tissues detected using the strict three compartment model became more apparent using the diffusional compartment model.
Since the incorporation of the diffusion constraints into compartmental models results in much longer solution times on the
computer, it appears advisable to use the diffusional-compartmental models only for further analysis of selected records after
significant features of interest have been detected using strictly compartmental models.
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关键词
Papillary Muscle,Compartmental Model,Kidney Cortex,Compartmental Effect,Bathing Medium
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