The 24-H Growth-Hormone (Gh) Secretion Profile In Patients With Diabetes-Mellitus-I (Idom) - Response Of Gh To Trh Administration

The growth hormone has been implicated in the pathogenesis of several metabolic derangements mainly with regard to vascular lesions specially proliferative retinophaty and nephropathy. It is known that in IDDM poorly controles there is an increase secretion of GH and anomalous responses to the hypothalamic hormones. There is absolutely no clear explanation to the increased GH secretion, but it is probable that IGF I (somatomedin) decreased levels do not block the somatostatin secretion and hence the GH4 secretion increases. In this paper, we studied 4 IDDM children (3 F and 1 M), 104/12 to 142/12 years old in which the GH secretion profile and TRH response was done in 2 separated occasions; with poor metabolic control and and TRH response was done in 2 separated occasions; with poor metabolic contro with “better” control. We used glycosilated hemoglobulin (hBAl C) as metabolic control parameter. Clinical and laboratory data of the 4 IDOM children are in the table. These data show that with better metabolic control there is decreased GH secretion (p < 0.05). Conclusion: Our data show that IDDM patients with better metabolic control had lower GH levels. These data suggest that better metabolic control increases somatostatin secretion and hence decreases GH secretion.