P.014 VASCULAR MARKERS OF PREMATURE ATHEROSCLEROSIS IN PAEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS AND DISEASE, THERAPY, METABOLIC AND INFLAMMATORY CORRELATES

Controversy exists as to whether the dyslipidemia and premature atherosclerosis which occurs in Systemic Lupus Erythematosus (SLE) is more due to disease activity or the therapy. We sought to determine the presence and correlates of vascular markers of premature atherosclerosis in paediatric SLE. Vascular assessment included: carotid intima-media thickness and brachial artery reactivity using vascular ultrasound; peripheral pulse wave velocity (PWV) using photoplethysmography; central PWV, arterial stiffness and impedance indices using an Echo-Doppler method. These vascular indices were converted to z-scores from normal population data, and tested for normality with single sample t-tests. Augmentation index and PWV, using applanation tonometry, were only assessed in the latter half of the cohort. Disease activity scores, disease duration, cumulative prednisone dose, other medication use and fasting lipid, glycemic and inflammatory profiles were also determined and Pearson correlations performed. Seventy paediatric SLE were assessed (median age 15.7 [7.3–18.7] years and diseased duration 1.4 [0.1–11.0] years, 80