Prevalence of Nickel Sensitization and Urinary Nickel Content of Children Are Increased by Nickel in Ambient Air
Environmental research(2011)
摘要
In a cross-sectional study performed in 2000, an unexpected positive association between nickel (Ni) in ambient air, urinary Ni content and the prevalence of Ni sensitization in a subgroup of 6-yr-old children living near a steel mill was observed. Between 2005 and 2006, in a different and larger study population, we examined if Ni from ambient air or urinary Ni concentration was related to Ni sensitization in children living next to Ni-emitting steel mills.We studied 749 school beginners living in four Ni-polluted industrial areas of North Rhine-Westphalia, Germany. We assessed Ni in ambient air, Ni in urine from children and mothers, and Ni in tap water, conducted patch tests in children (including the NiSO4-dilution test) and collected questionnaire data. Statistics were done by linear and logistic regression analyses, adjusted for covariates.At increased Ni concentration in ambient air (unit of increase: 10 ng/m(3)), urinary Ni concentrations rose in both mothers (9.1%; 95% Cl; 6.8-11.4%) and children (2.4%; 95% Cl: 0.4-4.4%). The prevalence of Ni sensitization in children was associated with increased Ni from ambient air (unit of increase: 18 ng/m3; odds ratio 128:95% Cl; 1.25-1.32) and urinary Ni concentration (unit of increase: 7.1 mu g/L; odds ratio 2.4; 95% Cl: 1.20-4.48). Ni in ambient air of areas with Ni-emitting factories contributes to internal Ni exposure in residents via inhalation and, furthermore, is a risk factor for the development of Ni sensitization in children. (C) 2010 Elsevier Inc. All rights reserved.
更多查看译文
关键词
Nickel,Air pollution,Skin sensitization,Urine,Children
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要