A Simple Synthesis Of Biaryl Phospholipase A(2) Inhibitors: Probing Hydrophobic Effects
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1996)
摘要
A series of biaryl acids has been synthesized by treating diphenic anhydride with a variety of amines. The one step strategy allows the rapid interchange of groups for evaluating the hydrophobic constraints of inhibitors of phopholipase A(2). The most active inhibitor synthesized displayed an IC50 = 6 mu M against human platelet phospholipase A(2). Copyright (C) 1996 Elsevier Science Ltd
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