Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.

Ping Chen,Charles G Caldwell,Wallace T Ashton,Joseph K Wu,Huaibing He,Kathryn A Lyons,Nancy A Thornberry,Ann E Weber

Bioorganic & Medicinal Chemistry Letters（2011）

引用 16|浏览26

暂无评分

摘要

A novel series of 4-substituted-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes 1 and piperidines 2 were prepared and evaluated for inhibition of dipeptidyl dipeptidase IV (DPP-4) for treatment of type 2 diabetes.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要