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Leukotriene E4–induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma

Annika Laitinen,Ari Lindqvist,Maija Halme,Alan Altraja,Lauri A. Laitinen

Journal of Allergy and Clinical Immunology（2005）

Cited 29|Views29
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Abstract
Conclusion Persistent LTE 4 -induced airway eosinophilia may form the basis of an amplification mechanism for further eosinophil recruitment. Zafirlukast prevents LTE 4 -induced eosinophilic airway inflammation in mild asthma.
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Key words
Asthma,airways,biopsies,CysLT1 receptor,LTE4,inflammation,eosinophilia
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