EFFECT OF PHYSICAL TRAINING ON FITNESS AND FATNESS IN WOMEN WITH SICKLE CELL DISEASE (SCD)
Medicine and science in sports and exercise(1999)
摘要
1842 Exercise recommendations for adults with SCD are vague and no studies have reported the effects of physical training (PT) in adults with SCD. We developed a PT program to determine safety and possible beneficial effects in women with SCD. Recruitment of 25 women resulted in 3 exclusions for failure to meet inclusion criteria or medical reasons. Baseline testing included: physical examination, RAND SF-36 health status survey, body composition by dual X-ray absorptiometry, peak VO2, and leg and bench press. Women were deconditioned at baseline as evidenced by a low peak VO2 (15.8 ± 1.1 ml/kg/min; mean ± SE), and high percent body fat (33.3 ± 2.8%). Monitored PT was offered 4 times/week and included 30 min of aerobic exercise and 20 min of resistance training. Only eight women (age 32.0 ± 3.4 yrs) completed 3-6 mo of PT, exercising at 74% peak HR, and returned for post-testing. Implementation of PT was feasible and did not induce acute events or worsen the overall clinical course. There was a significant (+ 24.5 kg) increase in leg strength (p = 0.007) which may enhance physical functioning in this population. Although the mean changes in peak VO2 (+0.04 ml/kg/min), arm strength (+ 3.6 kg), and % fat (−0.5%) were in favorable directions, they did not achieve significance (p>0.05). Scores on the RAND SF-36 did not change significantly. It appeared the intensity of exercise the women could maintain was insufficient to improve cardiovascular fitness or body composition in 3-6 months. Supported by NIH - (HD35063)
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