Cadmium ion stimulation of growth and versicolorin synthesis in a mutant strain ofAspergillus parasiticus
Experimental Mycology(1986)
摘要
Cultures ofAspergillus parasiticus produce the polyketide versicolorin A in response to elevation of the Zn2+ content of the growth medium. With suboptimal Zn2+ (0.8 μM) mycelial growth is about half maximal, and versicolorin synthesis is essentially zero. Inclusion of Cd2+ (1–100 μM) in the Zn2+-limiting growth medium allows optimal growth and stimulates full versicolorin synthesis. Cd2+, like Zn2+, will stimulate versicolorin sysnthesis only when added within the first 30 h after conidial inoculation. The transport system for Cd2+ uptake may be the same as that for Zn2+, as judged byin vivo competition studies. Cd2+ is a competitive inhibitor of Zn2+ uptake, with Ki = 20 μM.
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关键词
Aspergillus parasiticus,versicolorin synthesis,Zn2+ uptake,Cd2+ uptake,secondary metabolism
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