Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Switch control pocket inhibitors of p38-alpha kinase are described. X-ray crystallography reveals a unique mode of binding to the switch control pocket residues arginine 67 or arginine 70.

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关键词

p38 kinase inhibitor,Type II kinase inhibitor,Switch contol inhibitor,MAP kinase inhibitor,Arthritis

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