DNA image cytometry and human papillomavirus (HPV) detection help to select smears at high risk of high-grade cervical lesions.
JOURNAL OF PATHOLOGY(2001)
摘要
Three samples were submitted from women undergoing routine screening (n=910): two smears tone for routine cytology and one for DNA image cytometry) and a scrape for human papillomavirus (HPV) testing. DNA histograms were classified as suspect in cases of aneuploidy, polyploidy, and/or diploidy with a high proliferation rate. Follow-up was available in 239 cases, The primary end-point was the presence of a high-grade squamous intraepithelial lesion (HGSIL) at biopsy. Seventy women (7.7%) had a high-risk (HR) HPV infection and a suspect DNA profile. cytological abnormalities, 28 HGSILs were detected: four with a prior In 77 women with diagnosis of ASCUS tall HR-HPV infected including three with a suspect DNA profile), three with smears evocative of LGSIL tall with HR-HPV infection and a suspect DIVA profile), and 21 with smears evocative of HGSIL tall with HR-HPV infection and 20 with a suspect DNA profile). During the follow-up period, oat of 239 women with a cytologically normal smear at first entry five developed a HGSIL; all were HR-HPV-positive and four had a suspect DNA profile at the first smear. HR-HPV detection alone gives a sensitivity of 100% for the detection of HGSIL, with a specificity of 84.3%, whereas DNA measurement associated with HPV testing significantly enhances the specificity to 95.4%. Thus, the combination of HPV testing and DNA measurement provides a highly sensitive and specific evaluation of the risk of HGSIL on cervical smears. Copyright (C) 2001 John Wiley & Sons, Ltd.
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关键词
human papillomavirus,cytological screening,DNA image cytometry,cervical lesions
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