Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode.
Bioorganic & Medicinal Chemistry（2009）
摘要
A new co-crystal PDE4B structure pushes the usual ligand anchor Gln-443 out of the active site. Unprecedented resolution of C-terminal residues gives access to PDE4B/4D ligand design.
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关键词
Lead optimisation,Ligand docking,Induced fit,SAR
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