Effect of clarithromycin on experimental rhinovirus-16 colds: a randomized, double-blind, controlled trial
The American Journal of Medicine(2000)
摘要
PURPOSE: Macrolide antibiotics are frequently prescribed to patients with symptoms of a common cold. Despite their lack of proven antiviral activity, macrolide antibiotics may have anti-inflammatory actions, such as inhibition of mucus secretion and production of interleukins 6 and 8 by epithelial cells. Because the symptoms of rhinovirus colds are attributed to the inflammatory response to infection, we studied the effects of treatment with clarithromycin on the symptomatic and inflammatory response to nasal inoculation with rhinovirus.
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关键词
epithelial cell,controlled trial,drug therapy,control group
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