Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++

PLoS Computational Biology, 2010.

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Using GERP++ results in improved resolution of functional sequence elements in the human genome and reveals that a higher proportion of the human genome is under evolutionary constraint than was previously estimated

摘要

Computational efforts to identify functional elements within genomes leverage comparative sequence information by looking for regions that exhibit evidence of selective constraint. One way of detecting constrained elements is to follow a bottom-up approach by computing constraint scores for individual positions of a multiple alignment and...更多

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