Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists

Rémy C. Lemoine,Ann C. Petersen,Lina Setti,Lijing Chen,Jutta Wanner,Andreas Jekle,Gabrielle Heilek,André deRosier,Changhua Ji,David M. Rotstein

Bioorganic & Medicinal Chemistry Letters（2010）

引用 12|浏览21

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摘要

The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 4-aminopiperidine ring system found in several series of chemokine receptor CCR5 antagonists.

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关键词

5-Amino-3-azabicyclo[3.3.0]octane,4-Aminopiperidine,Replacement,CCR5 antagonists,Chemokine receptor

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