Preparation of [61Cu]-2-acetylpyridine thiosemicarbazone complex as a possible PET tracer for malignancies

Applied Radiation and Isotopes, no. 3 (2006): 337-341

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Abstract

Due to the interesting anti-proliferative properties of copper–thiosemicarbazone complexes, the production of a 61Cu-labeled thiosemicarbazone, i.e. 2-acetylpyridine thiosemicarbazone (APTS) was investigated. Copper-61 (T1/2=3.33h) was produced via the 64Zn(p,α)61Cu nuclear reaction using a natural zinc target irradiated with 22MeV proton...More

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