A case of late-onset Tourette's disorder successfully treated with aripiprazole: view from blood levels of catecholamine metabolites and brain-derived neurotrophic factor (BDNF).

We reported a case with late-onset Tourette's disorder (TD) in whom motor tics and emotional instability improved with 18 mg/day of aripiprazole treatment. Plasma HVA levels, but not MHPG levels, were altered during the treatment. In contrast, serum BDNF levels remained consistently low during the treatment course. The present case suggests that aripiprazole might ameliorate tics and emotional instability via influencing dopaminergic neurons in late-onset TD.