Induction and inhibition of cicletanine metabolism in cultured hepatocytes and liver microsomes from rats.

FUNDAMENTAL & CLINICAL PHARMACOLOGY, no. 5.0 (2000): 509-518

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Cicletanine, a racemic furopyridine derivative synthesized as racemate, is used as an antihypertensive agent. Its two enantiomers are involved in the pharmacological effects of the drug. Cicletanine is metabolized by conjugation enzyme systems (phase II) into sulfoconjugated or glucuroconjugated enantiomers. This study reports on the use ...更多

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