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The results showed that the antioxidant activity in aril juice correlated significantly to the total polyphenol and anthocyanin contents

Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, no. 23 (2007): 9559-9570

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摘要

Pomegranate juice is well known for its health beneficial compounds, which can be attributed to its high level of antioxidant activity and total polyphenol content. Our objective was to study the relationships between antioxidant activity, total polyphenol content, total anthocyanins content, and the levels of four major hydrolyzable tann...更多

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简介
  • The pomegranate tree and its fruit have been employed extensively in the folk medicine remedies of many cultures [1].
  • As described above for the aril juice, the polyphenol content in homogenates prepared from the whole fruit correlated positively with antioxidant activity (FRAP method) (r ) 0.95) (Table 3).
重点内容
  • The pomegranate tree and its fruit have been employed extensively in the folk medicine remedies of many cultures [1]
  • The beneficial health effects attributed to pomegranate fruit consumption are related, at least in part, to their antioxidant activity [23, 35]
  • Since pomegranate arils are largely consumed in our region, eaten freshly or used for salad dressings and in desserts, we first examined the level of antioxidant activity of juices prepared from the arils of 23 and 29 pomegranate accessions harvested in the 2005 and 2006 seasons, respectively
  • The level of ellagic acid was below the detection level under these conditions. The level of these four compounds in juices prepared from the arils did not correlate to antioxidant activity or polyphenol content (Table 2; Figures 2 and 3). These results strengthen the assumption that anthocyanins, which belong to the flavonoides group of polyphenols, and not the hydrolyzable tannins, are the major contributors to antioxidant activity in aril juice unlike in the juice prepared from the whole fruit
  • Since previously using in vitro and ex vivo assays it was shown that pomegranate juice (PJ) inhibits lipid peroxidation in plasma and low density lipoprotein (LDL) oxidation [10], we studied the ability of juices from different pomegranate accessions to inhibit LDL lipid peroxidation induced by copper ions
  • The results obtained for antioxidant activity, total polyphenol, and total anthocyanin contents (Figure 6) showed that while the antioxidant activity significantly correlated, as expected, with the polyphenol level (r ) 0.8, Table 5), it did not correlate with the level of anthocyanins, the arils contribute the main color to the juice
结果
  • The authors measured the levels of antioxidant activity, total phenol, and total anthocyanin contents in homogenates prepared from pomegranate peels.
  • An analysis of pomegranate juice prepared by hydrostatic pressure applied to the whole fruit showed that the predominant type of polyphenolic compounds extracted from the peels during the process is the water-soluble compounds of the hydrolyzable tannins, which accounts for 92% of its antioxidant activity [14].
  • The results showed that the levels of these four compounds are positively and significantly correlated to antioxidant activity and phenol level of homogenates prepared from the whole fruit and from the peels alone (Figures 4 and 5; Tables 3 and 4).
  • The results support the previous assumption [14, 50] that punicalagin originating from the peels is one of the major phytochemicals contributing to the total antioxidant capacity of pomegranate juice, while ellagic acid plays only a minor role in this activity [14].
  • The level of these four compounds in juices prepared from the arils did not correlate to antioxidant activity or polyphenol content (Table 2; Figures 2 and 3).
  • These results strengthen the assumption that anthocyanins, which belong to the flavonoides group of polyphenols, and not the hydrolyzable tannins, are the major contributors to antioxidant activity in aril juice unlike in the juice prepared from the whole fruit.
  • The results obtained for antioxidant activity, total polyphenol, and total anthocyanin contents (Figure 6) showed that while the antioxidant activity significantly correlated, as expected, with the polyphenol level (r ) 0.8, Table 5), it did not correlate with the level of anthocyanins, the arils contribute the main color to the juice.
结论
  • Both the percentage reduction in the oxidation of LDL measured by the thiobarbituric acid reactive substances (TBARS) assay and the percentage inhibition of LDL oxidation determined by the lipid peroxides assay (Figure 6, Table 5) positively and significantly correlated with the antioxidant capacity of the pomegranate juice having values of r ) 0.71, and r ) 0.82, respectively (Table 5).
  • In the current study, it was shown that juices prepared from the arils alone exhibit relatively poor antioxidant activity and low polyphenol content, as well as low content of the four hydrolyzable tannins, relative to homogenates prepared from the whole fruit.
表格
  • Table1: LC-MS Analysis of the Four Hydrolyzable Tannins compound punicalagin punicalin gallagic acid ellagic acid gradient number
  • Table2: Correlation Matrix between Antioxidant Activities Methods, Total Polyphenols, Total Anthocyanins, and the Levels of the Four Hydrolyzable Tannins in Juice Prepared from the Arils of the 29 Pomegranate Accessions According To the Pearson Test in the 2006 Seasona antioxidant activity FRAP antioxidant activity DPPH total polyphenols total anthocyanin punicalagin punicalin gallagic acid % arils antioxidant activity FRAP
  • Table3: Correlation Matrix (Pearson Test) Conducted on Data Obtained from Homogenates Prepared from the Whole Fruit of 29 Pomegranate Accessions in the 2006 Seasona antioxidant antioxidant total
  • Table4: Correlation Matrix (Pearson Test) (Pearson test) Conducted on the Data Obtained from Homogenates Prepared from the Peels Alone of 29 Pomegranate Accessions in the 2006 Seasona antioxidant activity FRAP antioxidant activity DPPH total polyphenols anthocyanin punicalagin ellagic acid punicalin gallagic acid % peels antioxidant activity FRAP
  • Table5: Correlation Matrix (Pearson test) (Spearman test) Conducted on Data Obtained from Juice Prepared from the Fruit Using a Juice Extractor of 23 Pomegranate Accessions in the 2005 Seasona antioxidant
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基金
  • Our research is supported by grants from the Israeli Ministry of Science (reference no. 0179/06; research no. 3-2316) and the JCA Charitable Foundation
研究对象与分析
members: 4
Antioxidant activity, total polyphenol content, total anthocyanin level, and juice color in aril juices prepared from 23 pomegranate accessions in the 2005 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity. Antioxidant activity, total polyphenol content, total anthocyanin level, juice color, and the content of four members of the hydrolyzable tannins in aril juices prepared from 29 pomegranate accessions in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity. Antioxidant activity, total polyphenol content, total anthocyanin level, and the content of four members of the hydrolyzable tannins in homogenates prepared from the whole fruit, of 29 pomegranate accessions used in this study in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity

members: 4
Antioxidant activity, total polyphenol content, total anthocyanin level, juice color, and the content of four members of the hydrolyzable tannins in aril juices prepared from 29 pomegranate accessions in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity. Antioxidant activity, total polyphenol content, total anthocyanin level, and the content of four members of the hydrolyzable tannins in homogenates prepared from the whole fruit, of 29 pomegranate accessions used in this study in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity. Antioxidant activity, total polyphenol content, total anthocyanin level, and the content of four members of the hydrolyzable tannins in homogenates prepared from the peels, of 29 pomegranate accessions used in this study in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity

members: 4
Antioxidant activity, total polyphenol content, total anthocyanin level, and the content of four members of the hydrolyzable tannins in homogenates prepared from the whole fruit, of 29 pomegranate accessions used in this study in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity. Antioxidant activity, total polyphenol content, total anthocyanin level, and the content of four members of the hydrolyzable tannins in homogenates prepared from the peels, of 29 pomegranate accessions used in this study in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity. Antioxidant activity, total polyphenol content, total anthocyanin level, the inhibitory effect on LDL oxidation, and the content of four members of the hydrolyzable tannins in homogenates prepared from the peels of 23 pomegranate accessions in the 2005 season. The effects of pomegranate juice supplementation on LDL oxidation were detected by two ex vivo assays. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity

members: 4
Antioxidant activity, total polyphenol content, total anthocyanin level, and the content of four members of the hydrolyzable tannins in homogenates prepared from the peels, of 29 pomegranate accessions used in this study in the 2006 season. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity. Antioxidant activity, total polyphenol content, total anthocyanin level, the inhibitory effect on LDL oxidation, and the content of four members of the hydrolyzable tannins in homogenates prepared from the peels of 23 pomegranate accessions in the 2005 season. The effects of pomegranate juice supplementation on LDL oxidation were detected by two ex vivo assays. The data presented represent the mean ( SD of five replicates from each accession; each of the replicates is a pool of two fruits. The R2 value was calculated against the antioxidant activity.

引用论文
  • (1) Langley, P. Why a pomegranate? BMJ 2000, 321, 1153–1154.
    Google ScholarLocate open access versionFindings
  • (2) Kim, N. D.; Mehta, R.; Yu, W.; Neeman, I.; Livney, T.; Amichay, A.; Poirier, D.; Nicholls, P.; Kirby, A.; Jiang, W.; Mansel, R.; Ramachandran, C.; Rabi, T.; Kaplan, B.; Lansky, E. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res. Treat. 2002, 71, 203–217.
    Google ScholarLocate open access versionFindings
  • (3) Lansky, E. P.; Harrison, G.; Mo, H.; Bravo, L.; Froom, P.; Yu, W.; Harris, N. M; Neeman, I.; Campbell, M. J. Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. InVest. New Drugs 2005, 23, 11–20.
    Google ScholarLocate open access versionFindings
  • (4) Adhami, V. M.; Mukhtar, H. Polyphenols from green tea and pomegranate for prevention of prostate cancer. Free Radic. Res. 2006, 40, 1095–1104.
    Google ScholarLocate open access versionFindings
  • (5) Malik, A.; Afaq, F.; Sarfaraz, S.; Adhami, V. M.; Syed, D. N.; Mukhtar, H. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 14813–14818.
    Google ScholarLocate open access versionFindings
  • (6) Malik, A.; Mukhtar, H. Prostate cancer prevention through pomegranate fruit. Cell Cycle 2006, 5, 371–373.
    Google ScholarLocate open access versionFindings
  • (7) Jeune, M. A.; Kumi-Diaka, J.; Brown, J. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J. Med. Food 2005, 8, 469–475.
    Google ScholarLocate open access versionFindings
  • (8) Adams, L. S.; Seeram, N. P.; Aggarwal, B. B.; Takada, Y.; Sand, D.; Heber, D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J. Agric. Food Chem. 2006, 54, 980–985.
    Google ScholarLocate open access versionFindings
  • (9) Khan, N.; Afaq, F.; Kweon, M. H.; Kim, K.; Mukhtar, H. Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res. 2007, 67, 3475–3482.
    Google ScholarLocate open access versionFindings
  • (10) Aviram, M.; Dornfeld, L.; Rosenblat, M.; Volkova, N.; Kaplan, M.; Coleman, R.; Hayek, T.; Presser, D.; Fuhrman, B. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am. J. Clin. Nutr. 2000, 71, 1062–1076.
    Google ScholarLocate open access versionFindings
  • (11) Cerda, B.; Llorach, R.; Ceron, J. J.; Espin, J. C.; Tomas-Barberan, F. A. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur. J. Nutr. 2003, 42, 18–28.
    Google ScholarLocate open access versionFindings
  • (12) Kaplan, M.; Hayek, T.; Raz, A.; Coleman, R.; Dornfeld, L.; Vaya, J.; Aviram, M. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 2001, 131, 2082–2089.
    Google ScholarLocate open access versionFindings
  • (13) Noda, Y.; Kaneyuki, T.; Mori, A.; Packer, L. Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J. Agric. Food Chem. 2002, 50, 166– 171.
    Google ScholarLocate open access versionFindings
  • (14) Gil, M. I.; Tomas-Barberan, F. A.; Hess-Pierce, B.; Holcroft, D. M.; Kader, A. A. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agric. Food Chem. 2000, 48, 4581–4589.
    Google ScholarLocate open access versionFindings
  • (15) Braga, L. C.; Shupp, J. W.; Cummings, C.; Jett, M.; Takahashi, J. A.; Carmo, L. S.; Chartone-Souza, E.; Nascimento, A. M. Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production. J. Ethnopharmacol. 2005, 96, 335–339.
    Google ScholarLocate open access versionFindings
  • (16) Vasconcelos, L. C.; Sampaio, F. C.; Sampaio, M.; Pereira, C.; Mdo, S.; Higino, J. S.; Peixoto, M. H. Minimum inhibitory concentration of adherence of Punica granatum Linn (pomegranate) gel against S. mutans, S. mitis and C. albicans. Braz. Dent. J. 2006, 17, 223–227.
    Google ScholarFindings
  • (17) Neurath, A. R.; Strick, N.; Li, Y. Y.; Debnath, A. K. Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. BMC Infect. Dis. 2004, 4, 41.
    Google ScholarLocate open access versionFindings
  • (18) Vidal, A.; Fallarero, A.; Pena, B. R.; Medina, M. E.; Gra, B.; Rivera, F.; Gutierrez, Y.; Vuorela, P. M. Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. J. Ethnopharmacol. 2003, 89, 295–300.
    Google ScholarLocate open access versionFindings
  • (19) Aviram, M.; Dornfeld, L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001, 158, 195–198.
    Google ScholarLocate open access versionFindings
  • (20) Aviram, M.; Rosenblat, M.; Gaitini, D.; Nitecki, S.; Hoffman, A.; Dornfeld, L.; Volkova, N.; Presser, D.; Attias, J.; Liker, H.; Hayek, T. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin. Nutr. 2004, 23, 423–433.
    Google ScholarLocate open access versionFindings
  • (21) Seeram, N. P.; Zhang, Y.; Reed, J. D.; Krueger, C. G.; Vaya, J. Pomegranate Phytochemicals. In Pomegranates: Ancient Roots to Modern Medicine; Seeram, N. P., Heber, D., Eds.; Taylor and Francis Group: New York, 2006; pp 3–29.
    Google ScholarFindings
  • (22) Azadzoi, K. M.; Schulman, R. N.; Aviram, M.; Siroky, M. B. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J. Urol. 2005, 174, 386–393.
    Google ScholarLocate open access versionFindings
  • (23) Rosenblat, M.; Aviram, M. Antioxidative Properties of Pomegranate: In Vitro Studies. In Pomegranates: Ancient Roots to Modern Medicine; Seeram, N. P., Heber, D., Eds.; Taylor and Francis Group: New York, 2006; pp 31–43.
    Google ScholarFindings
  • (24) Lansky, E.; Shubert, S.; Neeman, I. Production, Processing and Marketing of Pomegranate in Mediterranean Region: Advances in Research and Technology. In Proceedings of the symposium jointly organized by CIHEAM and Escuela Politecnica Superior de Orihuela Universidad Miguel Hernandez (EPSO-UMH), Orihuela, Spain, 1998.
    Google ScholarLocate open access versionFindings
  • (25) Seeram, N. P.; Zhang Y.; Heber, D. Commercialization of pomegranates: fresh fruit, beverages, and botanical extract. In Pomegranates: Ancient Roots to Modern Medicine; Seeram, N. P.; Heber, D., Eds.; Taylor and Francis Group: New York, 2006; pp. 187–198.
    Google ScholarFindings
  • (26) Rosenblat, M.; Hayek, T.; Aviram, M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006, 187, 363–371.
    Google ScholarLocate open access versionFindings
  • (27) Still, D. W. Pomegranates: a botanical perspective. In Pomegranates: Ancient Roots to Modern Medicine; Seeram, N. P., Heber, D., Eds.; Taylor and Francis Group: New York, 2006; pp 199– 211.
    Google ScholarFindings
  • (28) Aviram, M.; Dornfeld, L.; Kaplan, M.; Coleman, R.; Gaitini, D.; Nitecki, S.; Hofman, A.; Rosenblat, M.; Volkova, N.; Presser, D.; Attias, J.; Hayek, T.; Fuhrman, B. Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp. Clin. Res. 2002, 28, 49–62.
    Google ScholarLocate open access versionFindings
  • (29) Ben Nasr, C.; Ayed, N.; Metche, M. Quantitative determination of the polyphenolic content of pomegranate peel. Z. Lebensm.Unters. Forsch. 1996, 203, 374–378.
    Google ScholarLocate open access versionFindings
  • (30) Giusti, M.; Wrolstad, R. E. Characterization and measurement of anthocyanins by UV-visible spectroscopy. In Current Protocols in Food Analytical Chemistry; Wrolstad, R. E., Schwartz S. J., Eds.; John Wiley & Sons, Inc.: New York, 2001; pp F1.2.1– F1.2.13.
    Google ScholarFindings
  • (31) Han, K. H.; Sekikawa, M.; Shimada, K.; Hashimoto, M.; Hashimoto, N.; Noda, T.; Tanaka, H.; Fukushima, M. Anthocyanin-rich purple potato flake extract has antioxidant capacity and improves antioxidant potential in rats. Br. J. Nutr. 2006, 96, 1125– 1133.
    Google ScholarLocate open access versionFindings
  • (32) Aviram, M. Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients. Biochem. Med. 1983, 30, 111–118.
    Google ScholarLocate open access versionFindings
  • (33) Buege, J. A.; Aust, S. D. Microsomal lipid peroxidation. Methods Enzymol. 1978, 52, 302–310.
    Google ScholarLocate open access versionFindings
  • (34) El-Saadani, E. N.; El-Sayed, M.; Goher, M.; Nasear, A. Y.; Jurgens, G. A. sepctrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J. Lipid Res. 1989, 30, 627–630.
    Google ScholarLocate open access versionFindings
  • (35) Vaya, J.; Aviram, M. Nutritional antioxidants: mechanisms of action, analyses of activities and medical applications. Curr. Med. Chem. Immunol. Endocr. Metab. Agents 2001, 1, 99–117.
    Google ScholarLocate open access versionFindings
  • (36) Rapisarda, P.; Tomaino, A.; Lo Cascio, R.; Bonina, F.; De Pasquale, A.; Saija, A. Antioxidant effectiveness as influenced by phenolic content of fresh orange juices. J. Agric. Food Chem. 1999, 47, 4718–4723.
    Google ScholarLocate open access versionFindings
  • (37) Solomon, A.; Golubowicz, S.; Yablowicz, Z.; Grossman, S.; Bergman, M.; Gottlieb, H. E.; Altman, A.; Kerem, Z.; Flaishman, M. A. Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L.). J. Agric. Food Chem. 2006, 54, 7717–7723.
    Google ScholarLocate open access versionFindings
  • (38) Sellappan, S.; Akoh, C. C.; Krewer, G. Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries. J. Agric. Food Chem. 2002, 50, 2432–2438.
    Google ScholarLocate open access versionFindings
  • (39) Rababah, T. M.; Ereifej, K. I.; Howard, L. Effect of ascorbic acid and dehydration on concentrations of total phenolics, antioxidant capacity, anthocyanins, and color in fruits. J. Agric. Food Chem. 2005, 53, 4444–4447.
    Google ScholarLocate open access versionFindings
  • (40) Ranilla, L. G.; Genovese, M. I.; Lajolo, F. M. Polyphenols and antioxidant capacity of seed coat and cotyledon from Brazilian and Peruvian bean cultivars (Phaseolus vulgaris L.). J. Agric. Food Chem. 2007, 55, 90–98.
    Google ScholarLocate open access versionFindings
  • (41) Seeram, N. P.; Momin, R. A.; Nair, M. G.; Bourquin, L. D. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine 2001, 8, 362–369.
    Google ScholarLocate open access versionFindings
  • (42) Seeram, N. P.; Nair, M. Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechins. J. Agric. Food Chem. 2002, 50, 5308–5312.
    Google ScholarLocate open access versionFindings
  • (43) Ichikawa, H.; Ichiyanagi, T.; Xu, B.; Yoshii, Y.; Nakajima, M.; Konishi, T. Antioxidant activity of anthocyanin extract from purple black rice. J. Med. Food. 2001, 4, 211–218.
    Google ScholarLocate open access versionFindings
  • (44) Prior, R. L.; Cao, G.; Martin, A.; Sofic, E.; McEwen, J.; O’Brien, C.; Lischner, N.; Ehlenfeldt, M.; Kalt, W.; Mainland, C. M. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J. Agric. Food Chem. 1998, 46, 2686–2693.
    Google ScholarLocate open access versionFindings
  • (45) Aaby, K.; Skrede, G.; Wrolstad, R. E. Phenolic composition and antioxidant activities in flesh and achenes of strawberries (Fragaria ananassa). J. Agric. Food Chem. 2005, 53, 4032–4040.
    Google ScholarLocate open access versionFindings
  • (46) Ghiselli, A.; Nardini, M.; Baldi, A.; Scaccini, C. Antioxidant activity of different phenolic fractions separated from an italian red wine. J. Agric. Food Chem. 1998, 46, 361–367.
    Google ScholarLocate open access versionFindings
  • (47) George, F.; Figueiredo, P.; Toki, K.; Tatsuzawa, F.; Saito, N.; Brouillard, R. Influence of trans-cis isomerisation of coumaric acid substituents on colour variance and stabilisation in anthocyanins. Phytochemistry 2001, 57, 791–795.
    Google ScholarLocate open access versionFindings
  • (48) Drogoundi, P. D.; Tsipouridis, C. Physical and chemical characteristics of pomegranates. HortScience 2005, 40, 1200–1203.
    Google ScholarLocate open access versionFindings
  • (49) Kulkarni, A. P.; Aradhya, S. M.; Divakar, S. Isolation and identification of a radical scavenging antioxidant-punicalagin from pith and carpellary membrane of pomegranate fruit. Food Chem. 2004, 87, 551–557.
    Google ScholarLocate open access versionFindings
  • (50) Seeram, N. P.; Adams, L. S.; Hardy, M. L.; Heber, D. Rapid large scale purification of ellagitannins from pomegranate husk, a by product of the commercial juice industry. Sep. Purif. Technol. 2005, 41, 49–55.
    Google ScholarLocate open access versionFindings
  • (51) Lin, C. C.; Hsu, Y. F.; Lin, T. C. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am. J. Chin. Med. 1999, 27, 371–376.
    Google ScholarLocate open access versionFindings
  • (52) Chen, P. S.; Li, J. H.; Liu, T. Y.; Lin, T. C. Folk medicine Terminalia catappa and its major tannin component, punicalagin, are effective against bleomycin-induced genotoxicity in Chinese hamster ovary cells. Cancer Lett. 2000, 152, 115–122.
    Google ScholarLocate open access versionFindings
  • (53) Seeram, N. P.; Adams, L. S.; Henning, S. M.; Niu, Y.; Zhang, Y.; Nair, M. G.; Heber, D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J. Nutr. Biochem. 2005, 16, 360–367.
    Google ScholarLocate open access versionFindings
  • (54) Kulkarni, A. P.; Mahal, H. S.; Kapoor, S.; Aradhya, S. M. In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin. J. Agric. Food Chem. 2007, 55, 1491–1500.
    Google ScholarLocate open access versionFindings
  • (55) Cerda, B.; Ceron, J. J.; Tomas-Barberan, F. A.; Espin, J. C. Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J. Agric. Food Chem. 2003, 51, 3493–3501.
    Google ScholarLocate open access versionFindings
  • (56) Fuhrman, B.; Volkova, N.; Aviram, M. Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. J. Nutr. Biochem. 2005, 16, 570–576.
    Google ScholarLocate open access versionFindings
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