Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol

Vanessa Faugeroux,Yves Génisson,Yahya Salma,Patricia Constant,Michel Baltas

Bioorganic & Medicinal Chemistry（2007）

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摘要

Three (S)-prolinol-derived conformationally restricted analogues of the antitubercular agent ethambutol were prepared and tested against Mycobacterium tuberculosis.

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关键词

Tuberculosis,Arabinosyltransferase,Ethambutol,Imine,Reductive coupling,Hydrocyanation,Prolinol

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