Synthesis and biological activity of chloromethyl ketones of leucine enkephalin

John T. Pelton,Robert B. Johnston,James L. Balk,Charles J. Schmidt,Edward B. Roche

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS（1980）

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摘要

The chloromethyl ketones of leucine enkephalin and D-Ala 2 -leucine enkephalin have been synthesized and tested for biological activity in the guinea pig ileum assay. The derivatives show an increased potency in morphine-like action in comparison to the corresponding enkephalins.

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关键词

chloromethyl ketone,t-boc,thin layer chromatography,benzyl,bzl,cmk,t-butyloxycarbonyl,tlc,biological activity

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