Dihydropyridines: a new class of angiotensin II antagonists

Ronald T. Wester,Christian J. Mularski,George T. Magnus-Ayritey,Paul da Silva Jardine,Janet A. LaFlamme,Helen Berke,Donald L. Bussolotti,Albert L. Rauch,Karen W. Hoover,Christine A. Kennedy,Michael R. Burkard,Michael L. Mangiapane,Charles E. Aldinger,Kelvin Cooper,Philip A. Carpino

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1994）

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摘要

The syntheses and biological activities of dihydropyridine angiotensin II (AII) antagonists are described. Compounds such as 12 are examples of a new, structurally distinct class of AT(1)-selective agents.

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