Strep and the City: Unexpected Persistence of Early-Onset GBS Sepsis Despite Increased Intra-Partum Antibiotic Prophylaxis in an Urban University Hospital

Strategies to reduce early-onset sepsis (EOS) with group B streptococcus (GBS) have relied on the administration of maternal intra-partum antibiotics (IPA) to mothers with identified risk factors. We studied the relationship between IPA, risk factors, and EOS for 14 years in our hospital, an inner-city, tertiary center serving primarily poor, high-risk, African-American mothers.