Discovery of 3,5-Disubstituted-1h-pyrrolo[2,3-b]pyridines As Potent Inhibitors of the Insulin-Like Growth Factor-1 Receptor (IGF-1R) Tyrosine Kinase

Exploration of the SAR around a series of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines led to the discovery of novel pyrrolopyridine inhibitors of the IGF-1R tyrosine kinase. Several compounds demonstrated nanomolar potency in enzyme and cellular mechanistic assays.