α,β-Cyclic-β-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Gregory R. Ott,Naoyuki Asakawa,Rui-Qin Liu,Maryanne B. Covington,Mingxin Qian,Krishna Vaddi,Robert C. Newton,James M. Trzaskos,David D. Christ,Laurine Galya,Thomas Scholz,Will Marshall,James J.-W. Duan

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Selective inhibitors of TNF-α Converting Enzyme (TACE) based on novel oxaspiro[4.4]nonane β-benzamido hydroxamic scaffolds acids have been synthesized and evaluated.

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关键词

TACE,TNF-α converting enzyme,MMP,Matrix metalloprotease,β-Amino acid

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