The Design And Synthesis Of Novel Adenosine Agonists

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1996)

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摘要
The 2R and 2S-endo isomers of N-6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the At adenosine receptor. The 2S-endo isomer was equipotent to N-6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer. Copyright (C) 1996 Elsevier Science Ltd
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adenosine receptor
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