Chronic ingestion of Primex-Z, compared with other common fat sources, drives worse liver injury and enhanced susceptibility to bacterial infections

Maísa Mota Antunes,Ariane Barros Diniz,Hortência Maciel Castro-Oliveira, Gabriel Alvim Machado Mendes,Maria Alice Freitas-Lopes,Karen Marques de Oliveira Costa,Kassiana Mafra Bicalho,Brenda Naemi Lanza Nakagaki,Matheus Silvério Mattos,Camila Dutra Moreira de Miranda,Mateus Eustáquio Lopes,Alesandra Corte Reis Melão,Raquel Carvalho-Gontijo,Sridhar Radhakrishnnan,Matthew Ricci,Rafael Machado Rezende,Gustavo Batista Menezes

Nutrition（2021）

引用 3|浏览23

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摘要

•Different fat sources can lead to divergent profiles of liver inflammation.•Ingestion of Primex-Z, a non–trans fat, led to worse liver disease.•Chronic high diet ingestion caused depletion of liver macrophages.•Altered macrophage function in mice fed a high-fat diet predisposes to infections.

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关键词

NAFLD,Liver,Steatosis,Immune system,Diet,High-fat diet,In vivo imaging

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