A 2-Week, Polysomnographic, Safety Study of Sodium Oxybate in Obstructive Sleep Apnea Syndrome

Sodium oxybate (SXB) is approved for cataplexy and excessive daytime sleepiness in narcolepsy. Obstructive sleep apnea syndrome (OSAS) affects ∼9–50% of narcoleptics. Effects of 2-week SXB administration on apnea–hypopnea index (AHI), oxygen saturation (SaO2), and sleep architecture were investigated in OSAS patients.