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A monoclonal antibody which can distinguish between the two isotypes of human C4

Molecular Immunology, no. 1 (1987): 91-96

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Abstract

A monoclonal antibody to Human C4 (L003) has been shown to bind to the polymorphic C4d fragment of the alpha-chain of C4. Another monoclonal antibody (L001) was shown to bind to the beta-chain. L003 reacts differently with the two isotypes of C4, C4-A and C4-B. The equilibrium constant of L003 for C4-B is approx. 7-fold higher than that f...More

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