Human casein kinase II subunit α: Sequence of a processed (pseudo) gene and its localization on chromosome 11
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression(1992)
摘要
A human 4.3 kb genomic DNA fragment, containing the information of a processed (pseudo)gene of casein kinase II subunit α (CKIIα) was isolated and sequenced. The genomic CKIIα sequence is 99% homologous to the CKIIα cDNA, carries several nucleotide exchanges, a poly(A) stretch at its 3′ end and is flanked at both ends by a 16 bp repeat. It has a promoter-like region including two TATA boxes and a CAAT box. Although translation of transcripts would be terminated by a stop codon after two third of the coding region, the resulting protein would still contain the catalytic domains. However, so far Northern blots with a 3′ specific probe were negative. The 4.3 kb genomic fragment containing the processed CKIIα (pseudo)gene was mapped by in situ hybridization to chromosome 11p15.
更多查看译文
关键词
Casein kinase II subunit α,genomic DNA sequence,Chromosome localization,(Human)
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络