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A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes

BMC Dermatology, no. 1 (2004): 2-2

被引用21|浏览2
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BACKGROUND: TGM1(transglutaminase 1) is an enzyme that crosslinks the cornified envelope of mature keratinocytes. Appropriate expression of the TGM1 gene is crucial for proper keratinocyte function as inactivating mutations lead to the debilitating skin disease, lamellar ichthyosis. TGM1 is also expressed in squamous metaplasia, a consequ...更多

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