Intramolecular Migration of Co-Ordinated Platinum from a Sulfur to N7 in the Nucleopeptide Met-d(TpG) (5′-O-methioninate-n-ylcarbonylthymidine 2′-Deoxyguanosine Monophosphate) †

The nucleopeptide Met-d(TpG) (5'-O-methioninate-N-ylcarbonylthymidine 2'-deoxyguanosine monophosphate), containing a methionine moiety covalently linked to a TpG dinucleotide, upon reaction with platinum complexes, initially yielded platinum co-ordination to the sulfur atom, which subsequently is substituted by the N-7 atom of guanine for the reaction with monofunctional [Pt(dien)Cl]Cl (dien = diethylenetriamine); in the case of the cisplatin analogue [Pt(en)Cl-2] (en = ethane-1,2-diamine) formation of a stable S,N chelate takes place.