An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes.

Xiaojun Han,Rita Civiello,Sokhom S Pin,Kevin Burris,Lynn A Balanda,Jay Knipe,Shelly Ren,Tracey Fiedler,Kaitlin E Browman,Robert Macci,Matthew T Taber,Jie Zhang,Gene M Dubowchik

Bioorganic & Medicinal Chemistry Letters（2007）

引用 12|浏览20

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摘要

The synthesis and SAR of tetraazacyclopenta[a]indenes, pharmacokinetic properties and the anxiolytic activity of an orally dosed exemplary compound 9d (Ki 8.0nM) are reported.

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