3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization
Bioorganic & Medicinal Chemistry Letters(2009)
摘要
The discovery, synthesis and SAR of a novel series of 3-benzyl-1,3-oxazolidin-2-ones as positive allosteric modulators (PAMs) of mGluR2 is described which led to potent, metabolically stable and orally available mGluR2 PAMs.
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关键词
mGluR2,Positive allosteric modulator,Carbamate,Schizophrenia
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