Stereoselective synthesis of desloratadine derivatives as antagonist of histamine.

Gai-Zhi Liu,Hai-Wei Xu,Guang-Wei Chen,Peng Wang,Ya-Na Wang,Hong-Min Liu,De-Quan Yu

Bioorganic & Medicinal Chemistry（2010）

引用 27|浏览14

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摘要

A novel family of desloratadine derivatives as antagonist of histamine were prepared. Above three optimum structures display potent activity inhibiting histamine-induced effects.

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关键词

Desloratadine,γ-Alkylidene butenolides,Antiallergic activity,Synthesis

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