The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists
Bioorganic & Medicinal Chemistry Letters(2008)
摘要
The design and profile of a series of adamantyl-containing long acting β2-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using a guinea pig trachea tissue model. A focus was then placed on developing a robust synthetic route to ensure rapid delivery of material for clinical trials.
更多查看译文
关键词
β2,Adrenoreceptor,Adamantyl,Saligenin,Asthma,Crystalline
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络