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Wide-scale analysis of human functional transcription factor binding reveals a strong bias towards the transcription start site.

PloS one, no. 8 (2008): e807-e807

被引用71|浏览7
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摘要

Transcription factors (TF) regulate expression by binding to specific DNA sequences. A binding event is functional when it affects gene expression. Functionality of a binding site is reflected in conservation of the binding sequence during evolution and in over represented binding in gene groups with coherent biological functions. Functio...更多

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