Myocardial 123I-MIBG scintigraphy for differentiation of Lewy bodies disease from FTD

Clinical distinction between Lewy bodies disease (LBD) and frontotemporal dementia (FTD) is sometimes difficult. Nigrostriatal dopaminergic degeneration occurs in both LBD and FTD, limiting helpfulness of DAT imaging to differentiate these forms of dementia. Several studies have emphasized the usefulness of myocardial scintigraphy with 123Metaiodobenzylguanidine (123I-MIGB) in assessing the sympathetic nerve terminals in LBD demonstrating that cardiac 123I-MIGB uptake is decreased in patients with this disease.