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Sensitive bioassay of bupivacaine in human plasma by liquid-chromatography-ion trap mass spectrometry.

Journal of Pharmaceutical and Biomedical Analysis, no. 3 (2005): 587-592

Cited by: 6|Views20
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Abstract

A sensitive high-performance liquid chromatography–tandem mass spectrometric (HPLC–MS–MS) method, using an ion trap spectrometer, was developed for quantitation of bupivacaine in human plasma. Bupivacaine and an internal standard (ropivacaine) were extracted in a single step from 100μL of alkalinized plasma with diethyl-ether. The mobile ...More

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